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These pages are for educational purposes only. They are not medical advice or diagnostic tools. Genetic information should be interpreted by a qualified healthcare professional.

Gene Pages · MVP Pilot

Genes

Five genes · primary-source citations · interactive variant lookup

An evidence-first reference for the genes most commonly discussed in consumer DNA analysis. Each page covers what the gene does, the common variants, the clinical significance (with citations to ClinVar and primary literature), and how to look up your own genotype if you have raw data from 23andMe, AncestryDNA, MyHeritage, or VCF.

Pilot — 5 genes

Start here.

MTHFR — folate metabolism and methylationC677T and A1298C: what the evidence actually supports for plasma homocysteine, folate, and clinical outcomes. COMT — dopamine, stress, and the warrior/worrier storyThe Val158Met (rs4680) variant and how it shifts prefrontal dopamine clearance. CYP2D6 — drug metabolism's most variable enzymeStar alleles, metabolizer phenotypes, and CPIC-guided dosing for codeine, tamoxifen, and antidepressants. APOE — lipid transport and Alzheimer's riskThe ε2/ε3/ε4 alleles, defined by rs429358 and rs7412, and what each genotype means for lifetime risk. BRCA1 — hereditary breast and ovarian cancerWhy a consumer SNP test is not the right tool — and what the right tool looks like.

This is an MVP pilot. We will expand to 30 and then to 200 genes after evaluating real search demand, content quality, and conversion against signups.