DeepDNA Science Team
The DeepDNA Science Team combines expertise in computational genomics, bioinformatics, and data science to make genetic insights accessible. We review the latest research from peer-reviewed journals and translate complex genomics concepts into actionable knowledge.
Articles by DeepDNA Science Team
Read Your 23andMe File With Claude, Without Uploading It
Ask Claude about your 23andMe raw data while the file stays on your computer. A free local package reports curated positions; the file never reaches DeepDNA.
October 18, 2026 · 10 min readWhole Genome Sequenced and Never Used? What to Do With It
What to do with whole genome sequencing data: what to ask it once, how it changes the reading of your bloodwork, what long reads add, what it can't predict.
October 14, 2026 · 17 min readThe 23andMe API Is Gone: Reading 23andMe Data in Python
The 23andMe API was switched off in 2018 and api.23andme.com now redirects away. Read the raw data file in Python instead: format, pitfalls, GRCh38 remap.
October 11, 2026 · 9 min readA Pharmacogenomics MCP Server for Claude, Cursor and VS Code
Give your AI agent cited drug–gene records, most from CPIC and DPWG, instead of recall. One line to connect, no key: a medication screen and rsID lookups.
October 11, 2026 · 8 min readPharmGKB API Not Working? Migrate to ClinPGx in Python
PharmGKB API calls failing? api.pharmgkb.org no longer resolves. Move to api.clinpgx.org in Python with a 2 req/s throttle, loud errors and CPIC renames.
October 3, 2026 · 10 min readCYP2C19 and SLCO1B1 From a Raw DNA File in Python
Parse a 23andMe or AncestryDNA raw file, count CYP2C19 and SLCO1B1 marker alleles, see why that is not a clinical phenotype, and fetch cited drug guidance. Working code.
September 26, 2026 · 11 min readWhat Your AI Agent Needs to Know About Your Blood Test
A lab report is a PDF, not data. Here is why an agent reading it from memory gets the reference range wrong, what structured biomarkers look like, and how DNA and bloodwork read together.
September 20, 2026 · 9 min readHow to Let Your AI Agent Read Your DNA Without Handing It Your Genome
You have a raw DNA file and an AI agent. Here is what the agent should do, what a tool should do instead, what you can try today for free, and the five questions to ask before any upload.
September 20, 2026 · 10 min readCan ChatGPT Analyze Your Raw DNA Data? What Actually Works
ChatGPT can't read a 600,000-SNP file. Here's what happens when you try, the 3 errors it makes on one variant, and what actually works.
August 15, 2026 · 11 min readAncestryDNA Raw Data: Download and Analyze It (2026)
Your AncestryDNA raw data holds ~700,000 genotyped positions that Ancestry never interprets for health. How to download the file and analyze it yourself.
August 8, 2026 · 13 min readCRISPR 2026: What Gene Editing Can Actually Treat
One approved therapy, the first successful in-body trial, and the delivery problem holding back the rest — where CRISPR stands in 2026.
August 1, 2026 · 19 min readSingle-Cell RNA-Seq Analysis with AI: Tools and Best Practices
How to analyze single-cell RNA-seq data using AI tools like scGPT, Geneformer, Scanpy, and Seurat. A practical guide to the 2026 scRNA-seq workflow.
April 6, 2026 · 14 min readAlphaFold Impact on Drug Discovery Timelines
How AlphaFold compresses the structure step in drug discovery: the months-long bottleneck it removes, how Isomorphic and Recursion use it, and its limits.
March 28, 2026 · 14 min readProtein Language Models: The LLM Moment for Biology
ESM-2, ProtTrans and ProGen2 are protein LLMs — foundation models that read protein sequences like language to predict structure, function and evolution.
March 28, 2026 · 15 min readAI in Genomics: How Machine Learning Transforms DNA Analysis
How AI and machine learning are transforming genomics — from DeepVariant's variant calling to AlphaFold's protein predictions. What it means for your DNA.
March 27, 2026 · 18 min readCOMT Val158Met: The Warrior/Worrier Idea and the Evidence
COMT Val158Met (rs4680) changes enzyme activity 3- to 4-fold. What studies report for groups, why the effects are small, and why warrior/worrier is a hypothesis.
March 24, 2026 · 11 min readNight Owl or Lark? Chronotype Is 47% Genetic
Night owl or morning lark? Chronotype is up to 47% genetic. What PER2, CRY1 and CLOCK variants say about sleep timing, and why a questionnaire measures chronotype better than a DNA file.
March 22, 2026 · 10 min readVDR Gene and Vitamin D: What the Variants Do and Don't Tell You
The VDR gene encodes the vitamin D receptor. Variants like FokI and TaqI are linked in studies to supplementation response; your vitamin D status is measured by a blood test.
March 19, 2026 · 9 min readACTN3 Gene (R577X): What RR, RX and XX Mean
The ACTN3 gene builds a protein found only in fast-twitch muscle fibers. What the R577X variant means if you are RR, RX or XX — for sprint power and endurance.
March 18, 2026 · 9 min readFTO Gene and Weight: What Genetics Really Says About Obesity
The FTO gene is the strongest genetic link to body weight — but it's not what you think. Here's what your FTO variant actually does and why it's not destiny.
March 17, 2026 · 9 min readIs Lactose Intolerance Genetic? The LCT Gene Explained
Is lactose intolerance genetic? Yes — rs4988235 near the LCT gene shapes whether you digest milk as an adult. About 68% of adults worldwide do not.
March 17, 2026 · 10 min readCYP1A2 and Caffeine: What rs762551 Can and Can't Tell You
What the CYP1A2 rs762551 genotypes (AA, AC, CC) are associated with, what they cannot tell you about your own caffeine half-life, and the heart risk research.
March 15, 2026 · 9 min readPolygenic Risk Scores Explained: Should You Care?
A polygenic risk score combines thousands of DNA variants into one number. Learn what PRS can and cannot predict and its limits. 2026 guide.
March 15, 2026 · 10 min readHow DNA Testing Works: Saliva to Insights
Learn how DNA testing works — from saliva collection to SNP genotyping and results. Understand the science behind consumer genetic tests.
March 15, 2026 · 10 min readNutrigenomics Guide 2026: What Diet Genes Can and Can't Tell You
MTHFR, FTO, LCT, CYP1A2: what the evidence says about diet-related gene variants, and why none of them sets a personal diet. 2026 guide for raw DNA data.
March 15, 2026 · 15 min readWhat Are SNPs? The Tiny DNA Variants That Shape Your Health
SNPs are the most common genetic variants in your DNA. Learn what single nucleotide polymorphisms are, how they affect health, and why SNP analysis matters.
March 15, 2026 · 10 min readWhat Is DNA Analysis? Meaning, Methods and Costs
DNA analysis reads the variants in your genome to reveal traits, drug response and health risk. SNP genotyping vs whole genome sequencing — methods and costs.
March 13, 2026 · 15 min readDownload 23andMe Raw Data 2026: Yes, Even After Bankruptcy
Yes — 23andMe raw data download is still possible in 2026 after the bankruptcy. Step-by-step guide, what is in the file, and what to check before you upload it anywhere.
March 10, 2026 · 12 min readMTHFR Gene: What Your Variant Actually Means
The MTHFR gene is one of the most searched genetic variants. Here's what C677T and A1298C really mean for your health, based on evidence.
March 8, 2026 · 10 min readPharmacogenomics in Europe: DNA and Drug Response
Your genes influence how you metabolize medications. Learn about CYP2D6, CYP2C19, and why pharmacogenomics testing matters in Europe.
March 5, 2026 · 14 min readGDPR & Genetic Data: 9 Rights You Have in 2026
Your DNA is special-category data under GDPR Art. 9. Learn the 9 rights EU citizens have over genetic data, and how to enforce them in 5 minutes.
March 1, 2026 · 11 min read