{"variant":{"rsid":"rs4244285","gene":"CYP2C19","name":"*2 (c.681G>A)","alleles":"Plus strand, GRCh37 (as in 23andMe raw data): G reference, A variant, which defines *2. CYP2C19 is on the plus strand, so the letters match the gene. Copies of A at this one position are not a metabolizer status: that needs the other CYP2C19 variants and phasing.","effect":"Splice defect, no functional enzyme; the most common CYP2C19 loss-of-function allele worldwide. Poor and intermediate metabolizers form less active clopidogrel.","frequency_note":"~15% in Europeans, ~17% in Africans, ~29–35% in East Asians.","reading":{"assembly":"GRCh37","chromosome":"10","position":96541616,"reference_allele":"G","variant_allele":"A","gene_strand":"plus","countable":true,"strand_ambiguous":false,"sources":[{"label":"dbSNP rs4244285","url":"https://www.ncbi.nlm.nih.gov/snp/rs4244285"},{"label":"Ensembl GRCh37 rs4244285","url":"https://grch37.ensembl.org/Homo_sapiens/Variation/Explore?v=rs4244285"}]},"alphamissense":null,"sources":[{"label":"CPIC — CYP2C19 gene page","url":"https://cpicpgx.org/gene/cyp2c19/"},{"label":"PharmVar CYP2C19","url":"https://www.pharmvar.org/gene/CYP2C19"}]},"gene":{"symbol":"CYP2C19","name":"Cytochrome P450 Family 2 Subfamily C Member 19","url":"https://deepdna.ai/api/v1/genes/CYP2C19"},"meta":{"disclaimer":"Educational information only, not medical advice or diagnosis. Consult a clinician before acting on genetic information.","api_version":"2026-09-20","docs":"https://deepdna.ai/docs/","status":"live","data_as_of":"2026-10-25T21:32:19.251Z","freshness":"https://deepdna.ai/api/v1/freshness"}}